Ultrastructural Changes in Hypertrophied Myocardium of Spontaneously Hypertensive Rats
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-The aging spontaneously hypertensive rat (SHR) is a model in which the transition from chronic stable left ventricular hypertrophy to overt heart failure can be observed. Although the mechanisms for impaired function in hypertrophied and failing cardiac muscle from the SHR have been studied, none accounts fully for the myocardial contractile abnormalities. The cardiac cytoskeleton has been imp...
متن کاملCirculatory changes during pregnancy in spontaneously and renal hypertensive rats.
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متن کاملSpontaneously Hypertensive Rats
We have investigated whether differences seen in the pharmacological and morphological properties of mesenteric resistance vessels from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls are also present in vessels from young SHR and WKY rats in which there is little difference in blood pressure (BP). Segments of small arteries (lumen diameter 150 ̂ m) were taken ...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1976
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.40.1119